![]() ![]() ![]() Healthy individuals who experience this are typically aware that the “voices” they hear are false perceptions and originate from their mind. Schizophrenia patients experiencing AVH usually report that they have been hearing words, sentences and conversations which often comment on their thoughts. And cognitive-behavioral therapy, which is considered as the most investigated psychological intervention of AVH, has an average effect size of 0.44 ( 12). For example, transcranial magnetic stimulation may reduce the frequency and severity of AVH, but the efficacy effect size of 1 Hz transcranial magnetic stimulation was just 0.44, supported by meta-analysis ( 11). Brain stimulation and psychological intervention are also applied in the treatment for AVH, but the curative effect is not ideal. However, there are still a considerable minority of schizophrenia patients showing no treatment effect of antipsychotics ( 9) and AVH can be drug-resistant and become chronic in around 25% of schizophrenia patients ( 10). Studies have been conducted to investigate the efficacy of antipsychotic medications for AVH in schizophrenia patients, which exhibited a significant treatment effect of several typical and atypical antipsychotics ( 8, 9). Many efforts have been devoted to the treatment of auditory hallucinations, but the results still remain unsatisfactory ( 7). Schizophrenia patients with AVH may have an increased tendency toward violent behaviors or acts ( 4– 6), which may pose a threat and serious burden to society and their families.Ĭontrolling and eliminating symptoms of hearing voices is difficult in treatment. It occurs in 60–80% of schizophrenia patients ( 1) and causes multiple dysfunctions and poor control of behaviors ( 2, 3). Hopefully, our results could enhance understanding of the pathology of AVH.Īuditory verbal hallucinations (AVH) are vivid perceptions of sound that occur without corresponding external stimuli and have a strong sense of reality. However, no significant difference was found in N2 and Go P3 amplitude between the three groups.Ĭonclusions: AVH patients might have worse inhibitory top-down control, which might be involved in the occurrence of AVH. In all the groups, the parietal area showed smaller NoGo P3 than frontal and central areas. The two patient groups had smaller NoGo P3 amplitude than the healthy controls, and the AVH patients showed smaller NoGo P3 amplitude than the non-AVH patients. Results: Relative to healthy controls, the two patient groups observed longer reaction time (RT) and reduced accuracy. We employed event-related potentials to investigate the N2 and P3 amplitude and latency differences among these participants during a Go/NoGo task. Method: The present study recruited 40 schizophrenia patients, including 20 AVH patients and 20 non-AVH patients, and 23 healthy controls. Therefore, in this study, we focused on inhibitory top-down control in schizophrenia patients with AVH. Deficits of inhibitory top-down control may be linked to AVH. Objective: Auditory verbal hallucinations (AVH), with unclear mechanisms, cause extreme distresses to schizophrenia patients. 4Department Psychology, Xiangtan Central Hospital, Xiangtan, China.3Department of Clinical Psychology, The Third Xiangya Hospital of Central South University, Changsha, China.2Department of Clinical Psychology, Zhuzhou Central Hospital, Zhuzhou, China.1Department of Psychiatry, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, China.Qiaoling Sun 1 Yehua Fang 2 Yongyan Shi 1 Lifeng Wang 3 Xuemei Peng 1,4 * Liwen Tan 1 * ![]()
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